Evaluation of Hippocampal Segmentation Methods for Healthy and Pathological Subjects

Bishop, Courtney A.; Jenkinson, Mark; Declerck, Jerome; Merhof, Dorit

Evaluation of Hippocampal Segmentation Methods for Healthy and Pathological Subjects

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Date

2010

Authors

Bishop, Courtney A.
Jenkinson, Mark
Declerck, Jerome
Merhof, Dorit

Publisher

The Eurographics Association

Abstract

Hippocampal atrophy is a clinical biomarker of Alzheimer's disease (AD) and is implicated in many other neurological and psychiatric diseases. For this reason, there is much interest in the accurate, reproducible delineation of this region of interest (ROI) in structural MR images. Here, both current and novel MR hippocampal segmentation methods are presented and evaluated: Two versions of FMRIB's Integrated Registration and Segmentation Tool (FIRST and FIRSTv2), Freesurfer's Aseg (FS), Classifier Fusion (CF) and a Fast Marching approach (FMClose). Segmentation performance on two clinical datasets is assessed according to three common measures: Dice coefficient, false positive rate (FPR) and false negative rate (FNR). The first clinical dataset contains 9 normal controls (NC) and 8 highly-atrophied AD patients, whilst the second is a collection of 16 NC and 16 bipolar (BP) patients. Results show that CF outperforms all other methods on the BPSA data, whilst FIRST and FIRSTv2 perform best on the CMA data, with average Dice coefficients of 0.81+-0.01, 0.85+-0.00 and 0.85+-0.01, respectively. This work brings to light several strengths and weaknesses of the evaluated hippocampal segmentation methods, of utmost importance for robust and accurate segmentation in the presence of specific and substantial pathology.

        @inproceedings{10.2312:VCBM/VCBM10/017-024
,
booktitle = {Eurographics Workshop on Visual Computing for Biology and Medicine
},
editor = {Dirk Bartz and Charl Botha and Joachim Hornegger and Raghu Machiraju and Alexander Wiebel and Bernhard Preim
},
title = {{Evaluation of Hippocampal Segmentation Methods for Healthy and Pathological Subjects
}},
author = {Bishop, Courtney A. and 
Jenkinson, Mark and 
Declerck, Jerome and 
Merhof, Dorit
},
year = {2010
},
publisher = {The Eurographics Association
},
ISSN = {2070-5786
},
ISBN = {978-3-905674-28-6
},
DOI = {10.2312/VCBM/VCBM10/017-024
}
}