Cytosplore: Interactive Immune Cell Phenotyping for Large Single-Cell Datasets

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dc.contributor.authorHöllt, Thomasen_US
dc.contributor.authorPezzotti, Nicolaen_US
dc.contributor.authorUnen, Vincent vanen_US
dc.contributor.authorKoning, Fritsen_US
dc.contributor.authorEisemann, Elmaren_US
dc.contributor.authorLelieveldt, Boudewijn P. F.en_US
dc.contributor.authorVilanova, Annaen_US
dc.contributor.editorKwan-Liu Ma and Giuseppe Santucci and Jarke van Wijken_US
dc.date.accessioned2016-06-09T09:32:41Z
dc.date.available2016-06-09T09:32:41Z
dc.date.issued2016en_US
dc.description.abstractTo understand how the immune system works, one needs to have a clear picture of its cellular compositon and the cells' corresponding properties and functionality. Mass cytometry is a novel technique to determine the properties of single-cells with unprecedented detail. This amount of detail allows for much finer differentiation but also comes at the cost of more complex analysis. In this work, we present Cytosplore, implementing an interactive workflow to analyze mass cytometry data in an integrated system, providing multiple linked views, showing different levels of detail and enabling the rapid definition of known and unknown cell types. Cytosplore handles millions of cells, each represented as a high-dimensional data point, facilitates hypothesis generation and confirmation, and provides a significant speed up of the current workflow. We show the effectiveness of Cytosplore in a case study evaluation.en_US
dc.description.number3en_US
dc.description.sectionheadersBiological Data Visualizationen_US
dc.description.seriesinformationComputer Graphics Forumen_US
dc.description.volume35en_US
dc.identifier.doi10.1111/cgf.12893en_US
dc.identifier.issn1467-8659en_US
dc.identifier.pages171-180en_US
dc.identifier.urihttps://doi.org/10.1111/cgf.12893en_US
dc.identifier.urihttps://diglib.eg.org:443/handle/10
dc.publisherThe Eurographics Association and John Wiley & Sons Ltd.en_US
dc.subjectI.3.8 [Computer Graphics]en_US
dc.subjectApplicationsen_US
dc.titleCytosplore: Interactive Immune Cell Phenotyping for Large Single-Cell Datasetsen_US
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35-Issue 3
EuroVis16: Eurographics Conference on Visualization