Dirk-Bartz-Prize

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EuroVis 2021 Dirk Bartz Prize: Frontmatter
(The Eurographics Association, 2021) Oeltze-Jafra, Steffen; Raidou, Renata Georgia; Oeltze-Jafra, Steffen and Raidou, Renata Georgia
EuroVis 2023 - Dirk Bartz Prize: Frontmatter
(The Eurographics Association, 2023) Raidou, Renata; Kuhlen, Torsten; Raidou, Renata; Kuhlen, Torsten
Transdisciplinary Visualization of Aortic Dissections
(The Eurographics Association, 2023) Mistelbauer, Gabriel; Bäumler, Kathrin; Mastrodicasa, Domenico; Hahn, Lewis D.; Pepe, Antonio; Sandfort, Veit; Hinostroza, Virginia; Ostendorf, Kai; Schroeder, Aaron; Sailer, Anna M.; Willemink, Martin J.; Walters, Shannon; Preim, Bernhard; Fleischmann, Dominik; Raidou, Renata; Kuhlen, Torsten
Aortic dissection is a life-threatening condition caused by the abrupt formation of a secondary blood flow channel within the vessel wall. Patients surviving the acute phase remain at high risk for late complications, such as aneurysm formation and aortic rupture. The timing of these complications is variable, making long-term imaging surveillance crucial for aortic growth monitoring. Morphological characteristics of the aorta, its hemodynamics, and, ultimately, risk models impact treatment strategies. Providing such a wealth of information demands expertise across a broad spectrum to understand the complex interplay of these influencing factors. We present results of our longstanding transdisciplinary efforts to confront this challenge. Our team has identified four key disciplines, each requiring specific expertise overseen by radiology: lumen segmentation and landmark detection, risk predictors and inter-observer analysis, computational fluid dynamics simulations, and visualization and modeling. In each of these disciplines, visualization supports analysis and serves as communication medium between stakeholders, including patients. For each discipline, we summarize the work performed, the related work, and the results.
Visual Analysis of Tissue Images at Cellular Level
(The Eurographics Association, 2021) Somarakis, Antonios; Ijsselsteijn, Marieke E.; Kenkhuis, Boyd; Unen, Vincent van; Luk, Sietse J.; Koning, Frits; Weerd, Louise van der; Miranda, Noel F. C. C. de; Lelieveldt, Boudewijn P. F.; Höllt, Thomas; Oeltze-Jafra, Steffen and Raidou, Renata Georgia
The detailed analysis of tissue composition is crucial for the understanding of tissue functionality. For example, the location of immune cells related to a tumour area is highly correlated with the effectiveness of immunotherapy. Therefore, experts are interested in presence of cells with specific characteristics as well as the spatial patterns they form. Recent advances in single-cell imaging modalities, producing high-dimensional, high-resolution images enable the analysis of both of these features. However, extracting useful insight on tissue functionality from these high-dimensional images poses serious and diverse challenges to data analysis. We have developed an interactive, data-driven pipeline covering the main analysis challenges experts face, from the pre-processing of images via the exploration of tissue samples to the comparison of cohorts of samples. All parts of our pipeline have been developed in close collaboration with domain experts and are already a vital part in their daily analysis routine.
Visual Assistance in Clinical Decision Support
(The Eurographics Association, 2021) Müller, Juliane; Cypko, Mario; Oeser, Alexander; Stoehr, Matthäus; Zebralla, Veit; Schreiber, Stefanie; Wiegand, Susanne; Dietz, Andreas; Oeltze-Jafra, Steffen; Oeltze-Jafra, Steffen and Raidou, Renata Georgia
Clinical decision-making for complex diseases such as cancer aims at finding the right diagnosis, optimal treatment or best aftercare for a specific patient. The decision-making process is very challenging due to the distributed storage of patient information entities in multiple hospital information systems, the required inclusion of multiple clinical disciplines with their different views of disease and therapy, and the multitude of available medical examinations, therapy options and aftercare strategies. Clinical Decision Support Systems (CDSS) address these difficulties by presenting all relevant information entities in a concise manner and providing a recommendation based on interdisciplinary disease- and patient-specific models of diagnosis and treatment. This work summarizes our research on visual assistance for therapy decision-making. We aim at supporting the preparation and implementation of expert meetings discussing cancer cases (tumor boards) and the aftercare consultation. In very recent work, we started to address the generation of models underlying a CDSS. The developed solutions combine state-of-the-art interactive visualizations with methods from statistics, machine learning and information organization.
Visual Exploration of Intracranial Aneurysm Blood Flow Adapted to the Clinical Researcher
(The Eurographics Association, 2021) Behrendt, Benjamin; Engelke, Wito; Berg, Philipp; Beuing, Oliver; Hotz, Ingrid; Preim, Bernhard; Saalfeld, Sylvia; Oeltze-Jafra, Steffen and Raidou, Renata Georgia
Rupture risk assessment is a key to devise patient-specific treatment plans of cerebral aneurysms. To understand and predict the development of aneurysms and other vascular diseases over time, both hemodynamic flow patterns and their effect on the vessel surface need to be analyzed. Flow structures close to the vessel wall often correlate directly with local changes in surface parameters, such as pressure or wall shear stress. However, especially for the identification of specific blood flow characteristics that cause local startling parameters on the vessel surface, like elevated pressure values, an interactive analysis tool is missing. In order to find meaningful structures in the entirety of the flow, the data has to be filtered based on the respective explorative aim. Thus, we present a combination of visualization, filtering and interaction techniques for explorative analysis of blood flow with a focus on the relation of local surface parameters and underlying flow structures. In combination with a filtering-based approach, we propose the usage of evolutionary algorithms to reduce the overhead of computing pathlines that do not contribute to the analysis, while simultaneously reducing the undersampling artifacts. We present clinical cases to demonstrate the benefits of both our filter-based and evolutionary approach and showcase its potential for patient-specific treatment plans.
Visual Exploration, Analysis, and Communication of Physiological Processes
(The Eurographics Association, 2023) Garrison, Laura A.; Bruckner, Stefan; Raidou, Renata; Kuhlen, Torsten
Describing the myriad biological processes occurring in living beings over time, the science of physiology is complex and critical to our understanding of how life works. Physiology spans many spatio-temporal scales to combine and bridge from the basic sciences (biology, physics, and chemistry) to medicine. Recent years have seen an explosion of new and finer-grained experimental and acquisition methods to characterize these data. The volume and complexity of these data necessitate effective visualizations to complement standard analysis practice. Visualization approaches must carefully consider and be adaptable to the user’s main task, be it exploratory, analytical, or communication-oriented. This research contributes to the areas of theory, empirical findings, methods, applications, and research replicability in visualizing physiology. Our overarching theme is the cross-disciplinary application of medical illustration and visualization techniques to address challenges in exploring, analyzing, and communicating aspects of human physiology to audiences with differing expertise.
Visualizing Carotid Stenoses for Stroke Treatment and Prevention
(The Eurographics Association, 2023) Eulzer, Pepe; Richter, Kevin; Hundertmark, Anna; Meuschke, Monique; Wickenhöfer, Ralph; Klingner, Carsten M.; Lawonn, Kai; Raidou, Renata; Kuhlen, Torsten
Analyzing carotid stenoses - potentially lethal constrictions of the brain-supplying arteries - is a critical task in clinical stroke treatment and prevention. Determining the ideal type of treatment and point for surgical intervention to minimize stroke risk is considerably challenging. We propose a collection of visual exploration tools to advance the assessment of carotid stenoses in clinical applications and research on stenosis formation. We developed methods to analyze the internal blood flow, anatomical context, vessel wall composition, and to automatically and reliably classify stenosis candidates. We do not presume already segmented and extracted surface meshes but integrate streamlined model extraction and pre-processing along with the result visualizations into a single framework. We connect multiple sophisticated processing stages in one user interface, including a neural prediction network for vessel segmentation and automatic global diameter computation. We enable retrospective user control over each processing stage, greatly simplifying error detection and correction. The framework was developed and evaluated in multiple iterative user studies, involving a group of eight specialists working in stroke care (radiologists and neurologists). It is publicly available, along with a database of over 100 carotid bifurcation geometries that were extracted with the framework from computed tomography data. Further, it is a vital part of multiple ongoing studies investigating stenosis pathophysiology, stroke risk, and the necessity for surgical intervention.

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