SHREC 2021: Surface-based Protein Domains Retrieval

Langenfeld, Florent; Aderinwale, Tunde; Christoffer, Charles; Shin, Woong-Hee; Terashi, Genki; Wang, Xiao; Kihara, Daisuke; Benhabiles, Halim; Hammoudi, Karim; Cabani, Adnane; Windal, Feryal; Melkemi, Mahmoud; Otu, Ekpo; Zwiggelaar, Reyer; Hunter, David; Liu, Yonghuai; Sirugue, Léa; Nguyen, Huu-Nghia H.; Nguyen, Tuan-Duy H.; Nguyen–Truong, Vinh-Thuyen; Le, Danh; Nguyen, Hai-Dang; Tran, Minh-Triet; Montès, Matthieu

SHREC 2021: Surface-based Protein Domains Retrieval

Files

019-026.pdf (1.93 MB)

Date

2021

Publisher

The Eurographics Association

Abstract

Proteins are essential to nearly all cellular mechanism, and often interact through their surface with other cell molecules, such as proteins and ligands. The evolution generates plenty of different proteins, with unique abilities, but also proteins with related functions hence surface, which is therefore of primary importance for their activity. In the present work, we assess the ability of five methods to retrieve similar protein surfaces, using either their shape only (3D meshes), or their shape and the electrostatic potential at their surface, an important surface property. Five different groups participated in this challenge using the shape only, and one group extended its pre-existing algorithm to handle the electrostatic potential. The results reveal both the ability of the methods to detect related proteins and their difficulties to distinguish between topologically related proteins.

        @inproceedings{10.2312:3dor.20211308
,
booktitle = {Eurographics Workshop on 3D Object Retrieval
},
editor = {Biasotti, Silvia and Dyke, Roberto M. and Lai, Yukun and Rosin, Paul L. and Veltkamp, Remco C.
},
title = {{SHREC 2021: Surface-based Protein Domains Retrieval
}},
author = {Langenfeld, Florent and 
Aderinwale, Tunde and 
Windal, Feryal and 
Melkemi, Mahmoud and 
Otu, Ekpo and 
Zwiggelaar, Reyer and 
Hunter, David and 
Liu, Yonghuai and 
Sirugue, Léa and 
Nguyen, Huu-Nghia H. and 
Nguyen, Tuan-Duy H. and 
Nguyen–Truong, Vinh-Thuyen and 
Christoffer, Charles and 
Le, Danh and 
Nguyen, Hai-Dang and 
Tran, Minh-Triet and 
Montès, Matthieu and 
Shin, Woong-Hee and 
Terashi, Genki and 
Wang, Xiao and 
Kihara, Daisuke and 
Benhabiles, Halim and 
Hammoudi, Karim and 
Cabani, Adnane
},
year = {2021
},
publisher = {The Eurographics Association
},
ISSN = {1997-0471
},
ISBN = {978-3-03868-137-3
},
DOI = {10.2312/3dor.20211308
}
}